Drug Information
Drug General Information | Top | |||
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Drug ID |
D9P8LE
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Drug Name |
RG70099
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Drug Type |
Small molecular drug
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199] | Preclinical | [1] | |
Company |
Roche
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Indoleamine 2,3-dioxygenase 1 (IDO1) | Target Info | Inhibitor | [1] |
Tryptophan 2,3-dioxygenase (TDO) | Target Info | Inhibitor | [1] | |
BioCyc | Superpathway of tryptophan utilization | |||
Tryptophan degradation | ||||
L-kynurenine degradation | ||||
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | ||||
NAD de novo biosynthesis | ||||
KEGG Pathway | Tryptophan metabolism | |||
Metabolic pathways | ||||
African trypanosomiasis | ||||
NetPath Pathway | TSLP Signaling Pathway | |||
IL5 Signaling Pathway | ||||
TGF_beta_Receptor Signaling Pathway | ||||
Pathwhiz Pathway | Tryptophan Metabolism | |||
Reactome | Tryptophan catabolism | |||
WikiPathways | Tryptophan metabolism | |||
Metabolism of amino acids and derivatives |
References | Top | |||
---|---|---|---|---|
REF 1 | Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. |
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