Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D9D6QN
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| Drug Name |
SR1078
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| Synonyms |
1246525-60-9; SR 1078; SR-1078; N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-(trifluoromethyl)benzamide; CHEMBL3094387; N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-4-(trifluoromethyl)benzamide; N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide; SCHEMBL4880524; C17H10F9NO2; DTXSID30591895; BCP09203; EX-A2215; 4063AH; BDBM50444350; s5775; ZINC98052696; AKOS024458390; CS-1045; NCGC00379222-02; AK547149; AS-55921; HY-14422; W-5797; SR-03000001078; SR-03000001078-1; SR-03000001078-2
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| Drug Type |
Small molecular drug
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| Indication | Liver cancer [ICD-11: 2C12; ICD-10: C22] | Preclinical | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C17H10F9NO2
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| Canonical SMILES |
C1=CC(=CC=C1C(=O)NC2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O)C(F)(F)F
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| InChI |
1S/C17H10F9NO2/c18-15(19,20)11-3-1-9(2-4-11)13(28)27-12-7-5-10(6-8-12)14(29,16(21,22)23)17(24,25)26/h1-8,29H,(H,27,28)
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| InChIKey |
DUXWIYXHHGNUJU-UHFFFAOYSA-N
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| CAS Number |
CAS 1246525-60-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nuclear receptor ROR-alpha (RORA) | Target Info | Agonist | [2] |
| Nuclear receptor ROR-gamma (RORG) | Target Info | Agonist | [2] | |
| KEGG Pathway | Circadian rhythm | |||
| Inflammatory bowel disease (IBD) | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Reactome | RORA activates gene expression | |||
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
| PPARA activates gene expression | ||||
| Nuclear Receptor transcription pathway | ||||
| Circadian Clock | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| Adipogenesis | ||||
| Circadian Clock | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307. | |||
| REF 2 | Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORalpha and ROR. ACS Chem Biol. 2010 Nov 19;5(11):1029-34. | |||
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