Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D8U1EX
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| Drug Name |
SAR440340
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| Synonyms |
Itepekimab
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| Drug Type |
Antibody
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| Indication | Chronic obstructive pulmonary disease [ICD-11: CA22; ICD-10: J40-J44, J47; ICD-9: 490-492, 494-496] | Phase 3 | [1] | |
| Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Phase 2 | [2] | ||
| Company |
Regeneron Pharmaceuticals
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Interleukin-33 (IL33) | Target Info | . | [3] |
| KEGG Pathway | Cytosolic DNA-sensing pathway | |||
| Influenza A | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04701983) Randomized, Double-blind, Placebo-controlled, Parallel Group Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of SAR440340/REGN3500/Itepekimab (Anti-IL-33 mAb) in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD). U.S.National Institutes of Health. | |||
| REF 2 | ClinicalTrials.gov (NCT03387852) A Randomized, Double-blind, Placebo-controlled, Parallel-group, 12-week Proof-of-Concept (PoC) Study to Assess the Efficacy, Safety, and Tolerability of SAR440340 and the Coadministration of SAR440340 and Dupilumab in Patients With Moderate-to-Severe Asthma Who Are Not Well Controlled on Inhaled Corticosteroid (ICS) Plus Long-acting beta2 Adrenergic Agonist (LABA) Therapy. U.S.National Institutes of Health. | |||
| REF 3 | Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma. N Engl J Med. 2021 Oct 28;385(18):1656-1668. | |||
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