Drug Information
Drug General Information | Top | |||
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Drug ID |
D8JN5H
|
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Drug Name |
NKTR-262
|
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199] | Phase 1/2 | [1] | |
Melanoma [ICD-11: 2C30; ICD-9: 172] | Phase 1 | [2] | ||
Company |
Nektar Therapeutics
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Toll-like receptor 7 (TLR7) | Target Info | Agonist | [3] |
Toll-like receptor 8 (TLR8) | Target Info | Agonist | [3] | |
KEGG Pathway | Toll-like receptor signaling pathway | |||
Measles | ||||
Influenza A | ||||
NetPath Pathway | TCR Signaling Pathway | |||
Leptin Signaling Pathway | ||||
Panther Pathway | Toll receptor signaling pathway | |||
Reactome | Trafficking and processing of endosomal TLR | |||
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | ||||
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | ||||
MyD88 dependent cascade initiated on endosome | ||||
WikiPathways | Toll-like receptor signaling pathway | |||
Toll-Like Receptors Cascades | ||||
MyD88 dependent cascade initiated on endosome | ||||
Trafficking and processing of endosomal TLR | ||||
Regulation of toll-like receptor signaling pathway |
References | Top | |||
---|---|---|---|---|
REF 1 | ClinicalTrials.gov (NCT03435640) A Study of NKTR-262 in Combination With Bempegaldesleukin (NKTR-214) and With Bempegaldesleukin Plus Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumor Malignancies (REVEAL). U.S. National Institutes of Health. | |||
REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
REF 3 | Clinical pipeline report, company report or official report of Nektar Therapeutics. |
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