Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D6ETD2
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| Drug Name |
PTI-125
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| Synonyms |
UNII-6NV440YIO0; 6NV440YIO0; PTI-910; Simufilam; Simufilam [USAN]; SCHEMBL12627054; C0105M; WHO 11778; 1-benzyl-8-methyl-1,4,8-triazaspiro(4.5)decan-2-one; 1,4,8-Triazaspiro(4.5)decan-2-one, 8-methyl-1-(phenylmethyl)-; 1224591-33-6
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| Drug Type |
Small molecular drug
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| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Phase 2 | [1] | |
| Company |
Pain Therapeutics
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| Structure |
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Download2D MOL |
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| Formula |
C15H21N3O
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| Canonical SMILES |
CN1CCC2(CC1)NCC(=O)N2CC3=CC=CC=C3
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| InChI |
1S/C15H21N3O/c1-17-9-7-15(8-10-17)16-11-14(19)18(15)12-13-5-3-2-4-6-13/h2-6,16H,7-12H2,1H3
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| InChIKey |
BSQPTZYKCAULBH-UHFFFAOYSA-N
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| CAS Number |
CAS 1224591-33-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Filamin A (FLNA) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04388254) Simufilam (PTI-125), 100 mg, for Mild-to-moderate Alzheimer's Disease Patients (PTI-125). U.S. National Institutes of Health. | |||
| REF 2 | Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci. 2012 Jul 18;32(29):9773-84. | |||
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