Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D5VRX2
|
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| Drug Name |
Dociparstat sodium
|
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| Synonyms |
DSTAT
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|
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| Indication | Acute myeloid leukaemia [ICD-11: 2A60; ICD-9: 205] | Phase 3 | [1] | |
| Company |
Chimerix
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Platelet factor 4 (PF4) | Target Info | Inhibitor | [2] |
| Stromal cell-derived factor 1 (CXCL12) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Chemokine signaling pathway | ||||
| NF-kappa B signaling pathway | ||||
| Axon guidance | ||||
| Leukocyte transendothelial migration | ||||
| Intestinal immune network for IgA production | ||||
| Pathways in cancer | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | IL-7 Signaling Pathway | |||
| TWEAK Signaling Pathway | ||||
| Panther Pathway | Axon guidance mediated by Slit/Robo | |||
| Pathway Interaction Database | CXCR4-mediated signaling events | |||
| Syndecan-4-mediated signaling events | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Nuclear signaling by ERBB4 | |||
| Chemokine receptors bind chemokines | ||||
| G alpha (i) signalling events | ||||
| WikiPathways | EV release from cardiac cells and their functional effects | |||
| Signaling by ERBB4 | ||||
| Allograft Rejection | ||||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04571645) Dociparstat (DSTAT) in Combination With Standard Chemotherapy for the Treatment of Acute Myeloid Leukemia (AML) (DASH AML). U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of Chimerix. | |||
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