Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D5Q4NY
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| Drug Name |
TB47
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| Synonyms |
CHEMBL3612958; 1799682-71-5; 5-methoxy-2-methyl-~{N}-[[4-[4-[4-(trifluoromethyloxy)phenyl]piperidin-1-yl]phenyl]methyl]pyrazolo[1,5-a]pyridine-3-carboxamide; 5-Methoxy-2-methyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl)pyrazolo[1,5-a]pyridine-3-carboxamide; TB47; SCHEMBL19514093; HQECXZKIRDUGLC-UHFFFAOYSA-N; BDBM50598091; 5-methoxy-2-methyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]-1-piperidyl]phenyl]methyl]pyrazolo[1,5-a]pyridine-3-carboxamide; HV0
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| Drug Type |
Small molecule
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| Indication | Tuberculosis [ICD-11: 1B10-1B14] | Preclinical | [1] | |
| Company |
TB
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| Structure |
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Download2D MOL |
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| Formula |
C29H29F3N4O3
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| Canonical SMILES |
CC1=NN2C=CC(=CC2=C1C(=O)NCC3=CC=C(C=C3)N4CCC(CC4)C5=CC=C(C=C5)OC(F)(F)F)OC
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| InChI |
InChI=1S/C29H29F3N4O3/c1-19-27(26-17-25(38-2)13-16-36(26)34-19)28(37)33-18-20-3-7-23(8-4-20)35-14-11-22(12-15-35)21-5-9-24(10-6-21)39-29(30,31)32/h3-10,13,16-17,22H,11-12,14-15,18H2,1-2H3,(H,33,37)
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| InChIKey |
HQECXZKIRDUGLC-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cytochrome bc1 complex cytochrome b subunit (qcrB) | Target Info | Inhibitor | [2] |
| References | Top | |||
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| REF 1 | The QcrB Inhibitors TB47 and Telacebec Do Not Potentiate the Activity of Clofazimine in Mycobacterium abscessus. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0096421. | |||
| REF 2 | The QcrB Inhibitors TB47 and Telacebec Do Not Potentiate the Activity of Clofazimine in Mycobacterium abscessus. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0096421. | |||
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