Drug Information
Drug General Information | Top | |||
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Drug ID |
D5EHL4
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Drug Name |
Acoramidis
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Synonyms |
Acoramidis; AG-10; Acoramidis [USAN]; AG10; 1446711-81-4; T12B44A1OE; 3-[3-(3,5-Dimethyl-1h-Pyrazol-4-Yl)propoxy]-4-Fluorobenzoic Acid; UNII-T12B44A1OE; CHEMBL3940890; 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid; WHO 11205; Benzoic acid, 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluoro-; 4hiq; ACORAMIDIS [INN]; ACORAMIDIS [WHO-DD]; SCHEMBL15816954; BDBM50197885; AKOS040759821; HY-109165; CS-0116350; E79901; Q27451739; 16V
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Drug Type |
Small molecule
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Indication | Transthyretin amyloid cardiomyopathy [ICD-11: 5D00.20; ICD-10: E85.1] | Phase 3 | [1] | |
Company |
AstraZeneca
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Structure |
Download2D MOL |
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Formula |
C15H17FN2O3
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Canonical SMILES |
CC1=C(C(=NN1)C)CCCOC2=C(C=CC(=C2)C(=O)O)F
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InChI |
InChI=1S/C15H17FN2O3/c1-9-12(10(2)18-17-9)4-3-7-21-14-8-11(15(19)20)5-6-13(14)16/h5-6,8H,3-4,7H2,1-2H3,(H,17,18)(H,19,20)
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InChIKey |
WBFUHHBPNXWNCC-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Transthyretin (TTR) | Target Info | Modulator | [2] |
Pathway Interaction Database | FOXA2 and FOXA3 transcription factor networks | |||
Reactome | Retinoid cycle disease events | |||
The canonical retinoid cycle in rods (twilight vision) | ||||
Non-integrin membrane-ECM interactions | ||||
Retinoid metabolism and transport | ||||
Amyloid formation | ||||
WikiPathways | Visual phototransduction | |||
Extracellular matrix organization |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT03860935) A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of AG10 in Subjects With Symptomatic Transthyretin Amyloid Cardiomyopathy (ATTRibute-CM Trial). U.S.National Institutes of Health. | |||
REF 2 | Clinical pipeline report, company report or official report of AstraZeneca |
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