Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D53BVX
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| Drug Name |
Pemvidutide
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| Synonyms |
Pemvidutide; ALT801; GLXC-26955; 2538014-94-5
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| Drug Type |
Small molecule
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| Indication | Obesity [ICD-11: 5B81; ICD-10: E66] | Phase 1 | [1] | |
| Company |
Altimmune Gaithersburg, MD
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| Structure |
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Download2D MOL
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| Formula |
C178H270N38O53
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| Canonical SMILES |
CCC(C)C(C(=O)NC(CCC(=O)N)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(C(C)O)C(=O)N)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCCCNC(=O)C4C(C(C(C(O4)OCCCCCCCCCCCCCCCCCC(=O)O)O)O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)N)NC(=O)C(C)(C)NC(=O)C(CC8=CNC=N8)N
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| InChI |
InChI=1S/C178H270N38O53/c1-15-97(8)142(173(264)199-117(64-69-134(183)224)158(249)206-128(84-106-88-188-112-50-37-36-49-110(106)112)167(258)202-122(78-95(4)5)162(253)200-121(77-94(2)3)161(252)197-118(65-70-135(184)225)160(251)215-143(100(11)219)149(185)240)214-170(261)127(81-103-47-33-30-34-48-103)204-159(250)120(67-72-139(231)232)196-155(246)114(51-38-41-73-179)193-151(242)99(10)191-150(241)98(9)192-154(245)113(53-40-43-75-187-175(266)148-146(238)145(237)147(239)176(269-148)268-76-44-28-26-24-22-20-18-16-17-19-21-23-25-27-35-54-137(227)228)194-157(248)119(66-71-138(229)230)198-168(259)129(86-140(233)234)207-163(254)123(79-96(6)7)201-164(255)124(82-104-55-59-108(221)60-56-104)203-156(247)115(52-39-42-74-180)195-171(262)131(91-217)210-165(256)125(83-105-57-61-109(222)62-58-105)205-169(260)130(87-141(235)236)208-172(263)132(92-218)211-166(257)126(80-102-45-31-29-32-46-102)209-174(265)144(101(12)220)213-136(226)90-189-153(244)116(63-68-133(182)223)212-177(267)178(13,14)216-152(243)111(181)85-107-89-186-93-190-107/h29-34,36-37,45-50,55-62,88-89,93-101,111,113-132,142-148,176,188,217-222,237-239H,15-28,35,38-44,51-54,63-87,90-92,179-181H2,1-14H3,(H2,182,223)(H2,183,224)(H2,184,225)(H2,185,240)(H,186,190)(H,187,266)(H,189,244)(H,191,241)(H,192,245)(H,193,242)(H,194,248)(H,195,262)(H,196,246)(H,197,252)(H,198,259)(H,199,264)(H,200,253)(H,201,255)(H,202,258)(H,203,247)(H,204,250)(H,205,260)(H,206,249)(H,207,254)(H,208,263)(H,209,265)(H,210,256)(H,211,257)(H,212,267)(H,213,226)(H,214,261)(H,215,251)(H,216,243)(H,227,228)(H,229,230)(H,231,232)(H,233,234)(H,235,236)/t97-,98-,99-,100+,101+,111-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,142-,143-,144-,145-,146-,147+,148-,176+/m0/s1
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| InChIKey |
PNRXPXQSTNKDJB-VGUJMDGVSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Agonist | [2] |
| Glucagon-like peptide 1 receptor (GLP1R) | Target Info | Agonist | [2] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Insulin secretion | ||||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | |||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| Glucagon signaling in metabolic regulation | ||||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT05292911) A 12-Week Extension Study of ALT-801 in Diabetic and Non-Diabetic Overweight and Obese Subjects With Non-alcoholic Fatty Liver Disease (NAFLD). U.S.National Institutes of Health. | |||
| REF 2 | Effects of ALT-801, a GLP-1 and glucagon receptor dual agonist, in a translational mouse model of non-alcoholic steatohepatitis. Sci Rep. 2022 Apr 23;12(1):6666. | |||
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