Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D4TI9A
|
|||
| Drug Name |
JNJ-69086420
|
|||
| Drug Type |
Antibody
|
|||
| Indication | Prostate cancer [ICD-11: 2C82.0; ICD-9: 185] | Phase 1 | [1] | |
| Company |
Janssen
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tissue kallikrein (KLK2) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Endocrine and other factor-regulated calcium reabsorption | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Coregulation of Androgen receptor activity | |||
| Regulation of Androgen receptor activity | ||||
| Reactome | Activation of Matrix Metalloproteinases | |||
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
| WikiPathways | Prostate Cancer | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04644770) A Study of JNJ-69086420, an Actinium-225-Labeled Antibody Targeting Human Kallikrein-2 (hK2) for Advanced Prostate Cancer. U.S. National Institutes of Health. | |||
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