Drug Information
Drug General Information | Top | |||
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Drug ID |
D47MOS
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Drug Name |
Alofanib
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Synonyms |
1612888-66-0; 3-(N-(4-methyl-2-nitro-5-(pyridin-3-yl)phenyl)sulfamoyl)benzoic acid; RPT-835(alofanib); UNII-LQX7RFK8MZ; RPT-835; RPT835; LQX7RFK8MZ; ES000835; Alofanib [INN]; Alofanib(RPT835); Syn007154; CHEMBL4594436; SCHEMBL18660613; AMY16650; BCP31905; EX-A2731; MFCD30533418; NSC790182; s8754; Benzoic acid, 3-(((4-methyl-2-nitro-5-(3-pyridinyl)phenyl)amino)sulfonyl)-; NSC-790182; SB19665; AC-31695; AK668992; AS-56846; HY-17601; CS-0014684; RPT835; RPT-835; RPT 835; Q27283135; 3-{[4-methyl-2-nitro-5-(pyridin-3-yl)phenyl]sulfamoyl}benzoic acid
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Drug Type |
Small molecular drug
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Indication | Gastric adenocarcinoma [ICD-11: 2B72; ICD-9: 151] | Phase 1 | [1] | |
Structure |
Download2D MOL |
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Formula |
C19H15N3O6S
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Canonical SMILES |
CC1=CC(=C(C=C1C2=CN=CC=C2)NS(=O)(=O)C3=CC=CC(=C3)C(=O)O)[N+](=O)[O-]
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InChI |
1S/C19H15N3O6S/c1-12-8-18(22(25)26)17(10-16(12)14-5-3-7-20-11-14)21-29(27,28)15-6-2-4-13(9-15)19(23)24/h2-11,21H,1H3,(H,23,24)
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InChIKey |
QUQGQIASFYWKAB-UHFFFAOYSA-N
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CAS Number |
CAS 1612888-66-0
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Fibroblast growth factor receptor 2 (FGFR2) | Target Info | Inhibitor | [2] |
KEGG Pathway | MAPK signaling pathway | |||
Ras signaling pathway | ||||
Rap1 signaling pathway | ||||
Endocytosis | ||||
PI3K-Akt signaling pathway | ||||
Signaling pathways regulating pluripotency of stem cells | ||||
Regulation of actin cytoskeleton | ||||
Pathways in cancer | ||||
Prostate cancer | ||||
Central carbon metabolism in cancer | ||||
NetPath Pathway | IL1 Signaling Pathway | |||
Panther Pathway | FGF signaling pathway | |||
Pathway Interaction Database | FGF signaling pathway | |||
Reactome | Activated point mutants of FGFR2 | |||
WikiPathways | Regulation of Actin Cytoskeleton | |||
Ectoderm Differentiation | ||||
Hair Follicle Development: Organogenesis (Part 2 of 3) | ||||
Hair Follicle Development: Induction (Part 1 of 3) | ||||
Cardiac Hypertrophic Response | ||||
Signaling Pathways in Glioblastoma | ||||
Neural Crest Differentiation | ||||
Signaling by FGFR | ||||
MicroRNAs in cardiomyocyte hypertrophy | ||||
Angiogenesis |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT04071184) Study of Alofanib in Patients With Metastatic Gastric Cancer. U.S. National Institutes of Health. | |||
REF 2 | Corrigendum to 'Targeting FGFR2 with alofanib (RPT835) shows potent activity in tumour models' [Eur J Cancer 61 (2016) 20-28]. Eur J Cancer. 2017 Jan;70:156. |
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