Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D2KV8B
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| Drug Name |
AB-106
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| Synonyms |
DS6051b; GTPL11198; AB106
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Non-small-cell lung cancer [ICD-11: 2C25] | Phase 2 | [1] | |
| Company |
AnHeart Therapeutics
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H24FN5O
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| Canonical SMILES |
CC(COC1=CC=C(C=C1)C2=CN=C3N2N=C(C=C3)NC(C)C4=CC(=CC=C4)F)N
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| InChI |
1S/C23H24FN5O/c1-15(25)14-30-20-8-6-17(7-9-20)21-13-26-23-11-10-22(28-29(21)23)27-16(2)18-4-3-5-19(24)12-18/h3-13,15-16H,14,25H2,1-2H3,(H,27,28)
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| InChIKey |
HEVHTYMYEMEBPX-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Proto-oncogene c-Ros (ROS1) | Target Info | Inhibitor | [2] |
| Tropomyosin receptor kinase (Trk) | Target Info | Inhibitor | [2] | |
| WikiPathways | Spinal Cord Injury | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04395677) A Study of AB-106 in Subjects With Advanced NSCLC Harboring ROS1 Fusion Gene. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of AnHeart Therapeutics. | |||
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