Drug Information

Drug General Information

Drug ID

D24GYL

Drug Name

Lenacapavir

Synonyms

GS-6207; 2189684-45-3; N-[(1R)-1-[3-[4-Chloro-3-(cyclopropylsulfonylamino)-1-(2,2-difluoroethyl)indazol-7-yl]-6-(3-methyl-3-methylsulfonylbut-1-ynyl)pyridin-2-yl]-2-(3,5-difluorophenyl)ethyl]-2-[(2R,4S)-9-(difluoromethyl)-5,5-difluoro-7,8-diazatricyclo[4.3.0.02,4]nona-1(6),8-dien-7-yl]acetamide

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Drug Type

Small molecular drug

Indication

Human immunodeficiency virus-1 infection [ICD-11: 1C62; ICD-10: B20-B24; ICD-9: 42]

Approved

[1]

Human immunodeficiency virus infection [ICD-11: 1C62]

Phase 2/3

[2]

Company

Gilead Sciences

Structure

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2D MOL

Formula

C41H36ClF8N7O5S2

Canonical SMILES

CC(C)(C#CC1=NC(=C(C=C1)C2=C3C(=C(C=C2)Cl)C(=NN3CC(F)F)NS(=O)(=O)C4CC4)C(CC5=CC(=CC(=C5)F)F)NC(=O)CN6C7=C(C8CC8C7(F)F)C(=N6)C(F)F)S(=O)(=O)C

InChI

1S/C41H36ClF8N7O5S2/c1-40(2,63(3,59)60)11-10-22-4-7-24(25-8-9-28(42)33-36(25)56(17-30(45)46)54-39(33)55-64(61,62)23-5-6-23)34(51-22)29(14-19-12-20(43)15-21(44)13-19)52-31(58)18-57-37-32(35(53-57)38(47)48)26-16-27(26)41(37,49)50/h4,7-9,12-13,15,23,26-27,29-30,38H,5-6,14,16-18H2,1-3H3,(H,52,58)(H,54,55)/t26-,27+,29-/m1/s1

InChIKey

CPCUUUACFKQOHY-IUAQSZDVSA-N

PubChem Compound ID

138059678

Target and Pathway

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Target(s)

Human immunodeficiency virus Capsid p24 (HIV p24)

Target Info

Inhibitor

[3]

References

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REF 1

FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 215973.

REF 2

ClinicalTrials.gov (NCT04150068) Study to Evaluate the Safety and Efficacy of Lenacapavir in Combination With an Optimized Background Regimen in Heavily Treatment Experienced Participants Living With HIV-1 Infection With Multidrug Resistance (CAPELLA). U.S. National Institutes of Health.

REF 3

Clinical pipeline report, company report or official report of Gilead Sciences.

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