Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D1UA2E
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| Drug Name |
AM001
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| Synonyms |
MLS000562506; CHEMBL1407569; HMS2222P08; SMR000453693
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| Drug Type |
Small molecular drug
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| Indication | Actinic keratosis [ICD-11: EK90.0; ICD-10: L57.0; ICD-9: 702] | Phase 2 | [1] | |
| Company |
AmDerma Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C19H19N3O5
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| Canonical SMILES |
C#CCOC1CC(OC1CO)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3
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| InChI |
1S/C19H19N3O5/c1-2-10-26-14-11-17(27-15(14)12-23)22-9-8-16(21-19(22)25)20-18(24)13-6-4-3-5-7-13/h1,3-9,14-15,17,23H,10-12H2,(H,20,21,24,25)/t14-,15-,17-/m1/s1
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| InChIKey |
VUDFTOHJBXWAGS-BFYDXBDKSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Rap guanine nucleotide exchange factor 3 (RAPGEF3) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT03210740) Safety and Efficacy Study of AM001 Cream in the Treatment of Actinic Keratosis. U.S. National Institutes of Health. | |||
| REF 2 | Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress. Cardiovasc Res. 2019 Oct 1;115(12):1766-1777. | |||
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