Drug Information
Drug General Information | Top | |||
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Drug ID |
D0ZW5D
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Former ID |
DIB002070
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Drug Name |
LY-2409021
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Synonyms |
Oral glucagon receptor antagonist (type 2 diabetes), Eli Lilly
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Indication | Type-2 diabetes [ICD-11: 5A11; ICD-9: 250] | Phase 2 | [1] | |
Company |
Eli Lilly & Co
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Structure |
Download2D MOL |
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Formula |
C32H36F3NO4
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Canonical SMILES |
CC1=CC(=CC(=C1C2=CC=C(C=C2)C(C)(C)C)C)OC(CCC(F)(F)F)C3=CC=C(C=C3)C(=O)NCCC(=O)O
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InChI |
1S/C32H36F3NO4/c1-20-18-26(19-21(2)29(20)23-10-12-25(13-11-23)31(3,4)5)40-27(14-16-32(33,34)35)22-6-8-24(9-7-22)30(39)36-17-15-28(37)38/h6-13,18-19,27H,14-17H2,1-5H3,(H,36,39)(H,37,38)/t27-/m0/s1
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InChIKey |
FASLTMSUPQDLIB-MHZLTWQESA-N
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CAS Number |
CAS 1488363-78-5
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Glucagon receptor (GCGR) | Target Info | Antagonist | [2] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Glucagon signaling pathway | ||||
Reactome | Glucagon signaling in metabolic regulation | |||
G alpha (q) signalling events | ||||
G alpha (s) signalling events | ||||
Glucagon-type ligand receptors | ||||
WikiPathways | GPCRs, Class B Secretin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Integration of energy metabolism | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT02091362) A Study of LY2409021 on Blood Pressure and Pulse Rate in Participants With Type 2 Diabetes Mellitus. U.S. National Institutes of Health. | |||
REF 2 | Short-term administration of the glucagon receptor antagonist LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes. Diabetes Obes Metab. 2015 Apr;17(4):414-22. |
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