Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0ZU0O
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| Former ID |
DIB020937
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| Drug Name |
SEW2871
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| Synonyms |
SEW-2871; SEW 2871
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C20H10F6N2OS
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| Canonical SMILES |
C1=CC=C(C=C1)C2=C(SC(=C2)C3=NC(=NO3)C4=CC(=CC=C4)C(F)(F)F)C(F)(F)F
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| InChI |
1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
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| InChIKey |
OYMNPJXKQVTQTR-UHFFFAOYSA-N
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| CAS Number |
CAS 256414-75-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5991930, 9456564, 11538029, 24724607, 26540369, 26733769, 26753263, 26759552, 29215134, 35336212, 52640628, 53800523, 57356722, 71487884, 83100677, 85788696, 87624173, 99214894, 103512955, 104045123, 112614440, 118046685, 125335092, 126644833, 126666559, 135651038, 135697956, 141731683, 144104724, 151992558, 162023226, 162064813, 162088571, 162147084, 162991996, 163687303, 164225030, 164787849, 184529477, 184569849, 201504341, 204360395, 208264744, 223518277, 223542735, 223666151, 226759529, 246269603, 252156411, 252160351
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| ChEBI ID |
CHEBI:92283
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Sphingosine-1-phosphate receptor 1 (S1PR1) | Target Info | Agonist | [2] |
| KEGG Pathway | FoxO signaling pathway | |||
| Sphingolipid signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| IL2 Signaling Pathway | ||||
| Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | |||
| S1P3 pathway | ||||
| S1P1 pathway | ||||
| Sphingosine 1-phosphate (S1P) pathway | ||||
| PDGFR-beta signaling pathway | ||||
| Reactome | G alpha (i) signalling events | |||
| Lysosphingolipid and LPA receptors | ||||
| WikiPathways | Signal Transduction of S1P Receptor | |||
| Small Ligand GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2926). | |||
| REF 2 | Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem. 2004 Apr 2;279(14):13839-48. | |||
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