Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0ZM8B
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| Former ID |
DIB008724
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| Drug Name |
FK-409
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| Synonyms |
nor-3; 3-Hexenamide, 4-ethyl-2-(hydroxyimino)-5-nitro-; 92454-83-6; 163180-49-2; ACMC-20eif3; AC1OAT8P; 4-ethyl-2-hydroxyimino-5-nitrohex-3-enamide; CTK3H0114; CTK4D1460
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| Drug Type |
Small molecular drug
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| Indication | Angina pectoris [ICD-11: BA40; ICD-9: 413] | Phase 2 | [1] | |
| Company |
Fujisawa Pharmaceutical Co Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C8H13N3O4
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| Canonical SMILES |
CCC(=CC(=NO)C(=O)N)C(C)[N+](=O)[O-]
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| InChI |
1S/C8H13N3O4/c1-3-6(5(2)11(14)15)4-7(10-13)8(9)12/h4-5,13H,3H2,1-2H3,(H2,9,12)/b6-4+,10-7-
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| InChIKey |
MZAGXDHQGXUDDX-JSRXJHBZSA-N
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| CAS Number |
CAS 92454-60-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Soluble guanylyl cyclase (GUCY2D) | Target Info | Modulator | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The interaction of FK409, a novel nitric oxide releaser, and peripherally administered morphine during experimental inflammation. Anesth Analg. 1998 Feb;86(2):367-73. | |||
| REF 2 | Vasorelaxant mechanism of the new vasodilator, FK409. Eur J Pharmacol. 1993 Aug 15;246(3):205-12. | |||
| REF 3 | Tolerance to the vascular effect of a novel nitric oxide-donating vasodilator, FK409. Eur J Pharmacol. 1994 Aug 1;260(2-3):163-8. | |||
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