Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0ZM5B
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| Former ID |
DPR000011
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| Drug Name |
AG-021541
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| Synonyms |
SCHEMBL5880778
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| Drug Type |
Small molecular drug
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| Indication | Hepatitis C virus infection [ICD-11: 1E51.1; ICD-10: B18.2] | Discontinued in Phase 1 | [1] | |
| Company |
Agouron; Pfizer
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| Structure |
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Download2D MOL |
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| Formula |
C27H31ClN4O5S
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| Canonical SMILES |
CC1=CC(=NC2=NC(=NN12)SC3=C(CC(OC3=O)(CCC4=CC(=C(C=C4OC)OC)Cl)C5CCCC5)O)C
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| InChI |
1S/C27H31ClN4O5S/c1-15-11-16(2)32-25(29-15)30-26(31-32)38-23-20(33)14-27(37-24(23)34,18-7-5-6-8-18)10-9-17-12-19(28)22(36-4)13-21(17)35-3/h11-13,18,33H,5-10,14H2,1-4H3
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| InChIKey |
MKOFABQFNUCNTD-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) | Target Info | Inhibitor | [1], [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Emerging drugs for hepatitis C. Expert Opin Emerg Drugs. 2008 Mar;13(1):1-19. | |||
| REF 2 | In vitro resistance study of AG-021541, a novel nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase. Antimicrob Agents Chemother. 2008 Feb;52(2):675-83. | |||
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