Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Z9NY
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| Former ID |
DIB016803
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| Drug Name |
API-023
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| Synonyms |
AGN-201904; Proton pump inhibitor prodrug, Alevium; Proton pump inhibitor prodrug, Allergan; AGN-201904-Z; Omeprazole prodrug (GERD), Alevium
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| Indication | Gastroesophageal reflux disease [ICD-11: DA22.Z] | Phase 1 | [1] | |
| Company |
Allergan Inc
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Gastric H(+)/K(+) ATPase alpha (ATP4A) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Oxidative phosphorylation | |||
| Collecting duct acid secretion | ||||
| Gastric acid secretion | ||||
| Pathwhiz Pathway | Gastric Acid Production | |||
| Reactome | Ion transport by P-type ATPases | |||
| WikiPathways | Iron uptake and transport | |||
| Secretion of Hydrochloric Acid in Parietal Cells | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00325715) AGN 201904 Versus Esomeprazole in the Prevention of Aspirin-induced Stomach or Upper Intestinal Damage in Healthy Volunteers. U.S. National Institutes of Health. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 849). | |||
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