Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Z8DO
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| Former ID |
DND000093
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| Drug Name |
SPD-556
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| Synonyms |
M-0002
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| Drug Type |
Small molecular drug
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| Indication | Heart failure [ICD-11: BD10-BD13; ICD-10: I50, I50.9; ICD-9: 428] | Phase 2 | [1] | |
| Company |
Movetis
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| Structure |
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Download2D MOL |
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| Formula |
C21H18O5S
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| Canonical SMILES |
CC1=C(C=CC(=C1)O)C2(C3=CC=CC=C3S(=O)(=O)O2)C4=C(C=C(C=C4)O)C
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| InChI |
1S/C21H18O5S/c1-13-11-15(22)7-9-17(13)21(18-10-8-16(23)12-14(18)2)19-5-3-4-6-20(19)27(24,25)26-21/h3-12,22-23H,1-2H3
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| InChIKey |
OLQIKGSZDTXODA-UHFFFAOYSA-N
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| CAS Number |
CAS 2303-01-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
539652, 613318, 5709433, 8195527, 12157642, 43129068, 56366871, 74416217, 85084991, 85084992, 87572187, 92469641, 103062590, 103134235, 104354329, 117636144, 118498201, 125309626, 125331431, 126674145, 135148887, 136215308, 143545068, 143748808, 152042378, 162090197, 162180985, 162928312, 163419724, 164812001, 164812002, 176332622, 198969750, 223555411, 223665029, 226573971, 249837314, 250112769, 250217461, 252047452, 252363206
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Vasopressin V2 receptor (V2R) | Target Info | Antagonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Vasopressin-regulated water reabsorption | ||||
| Pathwhiz Pathway | Vasopressin Regulation of Water Homeostasis | |||
| Pathway Interaction Database | Arf6 trafficking events | |||
| Reactome | Vasopressin-like receptors | |||
| G alpha (s) signalling events | ||||
| Vasopressin regulates renal water homeostasis via Aquaporins | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Regulation of Water Balance by Renal Aquaporins | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01179607) Study of Efficacy of a Vasopressin 2 Receptor Antagonist M0002 for Treatment of Ascites in Cirrhotic Subjects With Hypo- or Normonatraemia. U.S. National Institutes of Health. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 368). | |||
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