Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Z5PM
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| Drug Name |
PMID29473428-Compound-80
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| Drug Type |
Small molecular drug
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| Company |
VERTEX PHARMACEUTICALS INCORPORATED
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| Structure |
 |
Download2D MOL |
||
| Formula |
C11H13ClN4O
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| Canonical SMILES |
COCCC1=C(C=CC(=C1)Cl)NC2=NNN=C2
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| InChI |
1S/C11H13ClN4O/c1-17-5-4-8-6-9(12)2-3-10(8)14-11-7-13-16-15-11/h2-3,6-7H,4-5H2,1H3,(H2,13,14,15,16)
|
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| InChIKey |
ZVGDDDHHESZRQT-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Indoleamine 2,3-dioxygenase 1 (IDO1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Indoleamine 2,3-dioxygenase 1 (IDO1) | Target's Patent Info | [1] | |
| BioCyc | Superpathway of tryptophan utilization | |||
| Tryptophan degradation | ||||
| L-kynurenine degradation | ||||
| Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | ||||
| NAD de novo biosynthesis | ||||
| KEGG Pathway | Tryptophan metabolism | |||
| Metabolic pathways | ||||
| African trypanosomiasis | ||||
| NetPath Pathway | TSLP Signaling Pathway | |||
| IL5 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Pathwhiz Pathway | Tryptophan Metabolism | |||
| Reactome | Tryptophan catabolism | |||
| WikiPathways | Tryptophan metabolism | |||
| Metabolism of amino acids and derivatives | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. | |||
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