Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Z4RC
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| Former ID |
DNCL002259
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| Drug Name |
CUDC-101
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| Synonyms |
CUDC-101; 1012054-59-9; CUDC 101; CUDC101; 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide; UNII-1A7Y9MP123; CHEMBL598797; 1A7Y9MP123; 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide; AK174946; 7-((4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide; 7-({4-[(3-ethynylphenyl)amino]-7-methoxyquinazolin-6-yl}oxy)-N-hydroxyheptanamide; 7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide; PubChem19149
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Company |
Curis
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H26N4O4
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| Canonical SMILES |
COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO
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| InChI |
1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20(19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7,11-12H2,2H3,(H,28,29)(H,25,26,27)
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| InChIKey |
PLIVFNIUGLLCEK-UHFFFAOYSA-N
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| CAS Number |
CAS 1012054-59-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
49660356, 56171066, 99437021, 103729562, 104162129, 124757071, 125163875, 131480726, 136340142, 136367359, 136920313, 137276021, 137618464, 143499549, 144115857, 152237699, 152258136, 152344190, 160646975, 162037496, 162202705, 163643062, 164045128, 164193971, 164838612, 174525778, 180414608, 185998813, 188899559, 198955528, 216125612, 223381965, 223704773, 226471483, 248177722, 252215203, 252451419
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | A Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2015 Apr 1;21(7):1566-73. | |||
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