Drug Information
Drug General Information | Top | |||
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Drug ID |
D0Z3PO
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Former ID |
DCL000725
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Drug Name |
BIIB014
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Synonyms |
V2006
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Drug Type |
Small molecular drug
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Indication | Parkinson disease [ICD-11: 8A00.0; ICD-9: 332] | Phase 2 | [1], [2] | |
Company |
Biogen Idec
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Structure |
Download2D MOL |
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Formula |
C16H15N7O
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Canonical SMILES |
CC1=C(C=CC(=C1)CN2C3=NC(=NC(=C3N=N2)C4=CC=CO4)N)N
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InChI |
1S/C16H15N7O/c1-9-7-10(4-5-11(9)17)8-23-15-14(21-22-23)13(19-16(18)20-15)12-3-2-6-24-12/h2-7H,8,17H2,1H3,(H2,18,19,20)
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InChIKey |
HQSBCDPYXDGTCL-UHFFFAOYSA-N
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CAS Number |
CAS 442908-10-3
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Adenosine A2a receptor (ADORA2A) | Target Info | Antagonist | [2] |
KEGG Pathway | Rap1 signaling pathway | |||
Calcium signaling pathway | ||||
cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Vascular smooth muscle contraction | ||||
Parkinson's disease | ||||
Alcoholism | ||||
Pathwhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | |||
Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
Reactome | NGF-independant TRKA activation | |||
Adenosine P1 receptors | ||||
G alpha (s) signalling events | ||||
Surfactant metabolism | ||||
WikiPathways | Nucleotide GPCRs | |||
Monoamine Transport | ||||
GPCRs, Class A Rhodopsin-like | ||||
NGF signalling via TRKA from the plasma membrane | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5612). | |||
REF 2 | Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006 Oct;5(10):845-54. |
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