Drug Information
Drug General Information | Top | |||
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Drug ID |
D0Z3CK
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Former ID |
DIB019430
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Drug Name |
PMID22533316C3
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Synonyms |
GTPL6711; BDBM50255473
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
Structure |
Download2D MOL
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Formula |
C21H25BrN2O2S
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Canonical SMILES |
CCN(CCCCOC1=CC2=C(C=C1)C(=NS2)C3=CC=C(C=C3)Br)CCO
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InChI |
1S/C21H25BrN2O2S/c1-2-24(12-13-25)11-3-4-14-26-18-9-10-19-20(15-18)27-23-21(19)16-5-7-17(22)8-6-16/h5-10,15,25H,2-4,11-14H2,1H3
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InChIKey |
XHOKJNHLSGAYJL-UHFFFAOYSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Lanosterol synthase (LSS) | Target Info | Inhibitor | [1] |
BioCyc | Cholesterol biosynthesis II (via 24,25-dihydrolanosterol) | |||
Cholesterol biosynthesis III (via desmosterol) | ||||
Cholesterol biosynthesis I | ||||
Superpathway of cholesterol biosynthesis | ||||
Lanosterol biosynthesis | ||||
KEGG Pathway | Steroid biosynthesis | |||
Metabolic pathways | ||||
Biosynthesis of antibiotics | ||||
Panther Pathway | Cholesterol biosynthesis | |||
Pathwhiz Pathway | Steroid Biosynthesis | |||
Reactome | Cholesterol biosynthesis | |||
Activation of gene expression by SREBF (SREBP) | ||||
WikiPathways | Activation of Gene Expression by SREBP (SREBF) | |||
SREBP signalling | ||||
Cholesterol Biosynthesis | ||||
Cholesterol biosynthesis |
References | Top | |||
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REF 1 | Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells. J Med Chem. 2012 Jun 14;55(11):4990-5002. | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6711). |
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