Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Z1RJ
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| Former ID |
DIB001406
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| Drug Name |
Adaphostin
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| Synonyms |
NSC-680410; NSC-726814; 241127-58-2
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| Drug Type |
Small molecular drug
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| Indication | Chronic myelogenous leukaemia [ICD-11: 2A20.0; ICD-10: C92.1; ICD-9: 205.1] | Phase 1 | [1] | |
| Company |
Mayo Foundation
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| Structure |
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Download2D MOL |
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| Formula |
C24H27NO4
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| Canonical SMILES |
C1C2CC3CC1CC(C2)(C3)OC(=O)C4=CC=C(C=C4)NCC5=C(C=CC(=C5)O)O
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| InChI |
1S/C24H27NO4/c26-21-5-6-22(27)19(10-21)14-25-20-3-1-18(2-4-20)23(28)29-24-11-15-7-16(12-24)9-17(8-15)13-24/h1-6,10,15-17,25-27H,7-9,11-14H2
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| InChIKey |
YJZSUCFGHXQWDM-UHFFFAOYSA-N
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| CAS Number |
CAS 241127-58-2
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fusion protein Bcr-Abl (Bcr-Abl) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | New strategies in chronic myeloid leukemia. Int J Hematol. 2006 May;83(4):289-93. | |||
| REF 2 | Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro. Blood. 2002 Jan 15;99(2):664-71. | |||
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