Drug Information
Drug General Information | Top | |||
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Drug ID |
D0Z0YB
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Former ID |
DNC007548
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Drug Name |
N-benzyl-9-oxo-9,10-dihydroacridine-3-carboxamide
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Synonyms |
Acridone-Based Inhibitor, 8c; N-benzyl-9-oxo-9,10-dihydroacridine-3-carboxamide; CHEMBL230199
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
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Download2D MOL |
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Formula |
C21H16N2O2
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Canonical SMILES |
C1=CC=C(C=C1)CNC(=O)C2=CC3=C(C=C2)C(=O)C4=CC=CC=C4N3
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InChI |
1S/C21H16N2O2/c24-20-16-8-4-5-9-18(16)23-19-12-15(10-11-17(19)20)21(25)22-13-14-6-2-1-3-7-14/h1-12H,13H2,(H,22,25)(H,23,24)
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InChIKey |
YUICSGTVFUPFFC-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) | Target Info | Inhibitor | [1] |
BioCyc | Purine nucleotides degradation | |||
Urate biosynthesis/inosine 5'-phosphate degradation | ||||
Guanosine nucleotides de novo biosynthesis | ||||
Superpathway of purine nucleotide salvage | ||||
Purine nucleotides de novo biosynthesis | ||||
Guanosine ribonucleotides de novo biosynthesis | ||||
KEGG Pathway | Purine metabolism | |||
Drug metabolism - other enzymes | ||||
Metabolic pathways | ||||
Panther Pathway | De novo purine biosynthesis | |||
Reactome | Purine ribonucleoside monophosphate biosynthesis |
References | Top | |||
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REF 1 | Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1... J Med Chem. 2007 Jul 26;50(15):3730-42. |
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