Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Z0PB
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| Former ID |
DCL000178
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| Drug Name |
NGD-8243
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| Synonyms |
SCHEMBL17320582
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| Drug Type |
Small molecular drug
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| Indication | Acute or chronic pain [ICD-11: MG30-MG31; ICD-10: R52, G89; ICD-9: 338780] | Discontinued in Phase 2 | [1] | |
| Therapeutic Class |
Analgesics
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| Company |
Neurogen Corp
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H12F6N4
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| Canonical SMILES |
C1=CC(=C(N=C1)C2=CC3=C(C=C2)C(=NC=N3)NC4=CC=C(C=C4)C(F)(F)F)C(F)(F)F
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| InChI |
1S/C21H12F6N4/c22-20(23,24)13-4-6-14(7-5-13)31-19-15-8-3-12(10-17(15)29-11-30-19)18-16(21(25,26)27)2-1-9-28-18/h1-11H,(H,29,30,31)
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| InChIKey |
VTANGSDRFFLTSQ-UHFFFAOYSA-N
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| CAS Number |
CAS 573678-04-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Blocker | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023970) | |||
| REF 2 | Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. | |||
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