Drug Information
Drug General Information | Top | |||
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Drug ID |
D0Z0MG
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Former ID |
DAP001552
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Drug Name |
Carglumic acid
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Synonyms |
Carbaglu (TN)
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Drug Type |
Small molecular drug
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Indication | Acute hyperammonaemia [ICD-11: 5C50.A; ICD-10: E72.2; ICD-9: 270.6] | Approved | [1], [2] | |
Company |
Orphan Europe
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Structure |
Download2D MOL |
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Formula |
C6H10N2O5
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Canonical SMILES |
C(CC(=O)O)C(C(=O)O)NC(=O)N
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InChI |
1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1
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InChIKey |
LCQLHJZYVOQKHU-VKHMYHEASA-N
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CAS Number |
CAS 1188-38-1
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PubChem Compound ID | ||||
PubChem Substance ID |
8123, 10239613, 15042291, 29301998, 49972812, 51091469, 57339753, 75361936, 99246024, 99443290, 103771504, 104413359, 118313708, 126690950, 128469986, 135075870, 137156454, 143438537, 144206097, 144229638, 146521207, 160646400, 160820463, 160967907, 162475756, 163380131, 163900960, 164817230, 170466164, 172860574, 175268265, 179116996, 184577038, 187051761, 202557029, 204429975, 223390500, 223535818, 223656021, 226705276, 249855635, 250210639, 252074316, 252360749, 252408967, 252476016
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ChEBI ID |
CHEBI:71028
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ADReCS Drug ID | BADD_D00368 | |||
SuperDrug ATC ID |
A16AA05
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Target and Pathway | Top | |||
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Target(s) | Carbamoyl-phosphate synthetase I (CPS1) | Target Info | Activator | [2] |
BioCyc | Urea cycle | |||
KEGG Pathway | Alanine, aspartate and glutamate metabolism | |||
Arginine and proline metabolism | ||||
Nitrogen metabolism | ||||
Metabolic pathways | ||||
Carbon metabolism | ||||
Biosynthesis of amino acids | ||||
Panther Pathway | Arginine biosynthesis | |||
De novo pyrimidine ribonucleotides biosythesis | ||||
Pathwhiz Pathway | Glutamate Metabolism | |||
Ammonia Recycling | ||||
Arginine and Proline Metabolism | ||||
Urea Cycle | ||||
WikiPathways | Urea cycle and metabolism of amino groups | |||
Metabolism of amino acids and derivatives |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7458). | |||
REF 2 | Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. |
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