Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0YZ0B
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| Former ID |
DIB003807
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| Drug Name |
HT-2678
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| Synonyms |
GABA inverse agonist (cognitive disorder) Helicon; HT-4313; GABA A receptor alpha-5 subunit modulator (cognitive disorder), Helicon Therapeutics
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| Indication | Cognitive impairment [ICD-11: 6D71; ICD-10: F06.7] | Investigative | [1] | |
| Company |
Helicon Therapeutics Inc
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-5 (GABRA5) | Target Info | Agonist | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). | |||
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