Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0YY5J
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| Drug Name |
US8921389, 1
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| Synonyms |
CHEMBL3671864; SCHEMBL12503126; RKTAODJRDMTRFE-UHFFFAOYSA-N; BDBM141545; US8921389, 1; [(1-Benzyl-5-hydroxy-2-oxo-1,2,3,4-tetrahydro-[1,7]naphthyridine-6-carbonyl)-amino]-acetic acid; [(1-Benzyl-5-hydroxy-2-oxo-1,2,3,4-tetrahydro-[1,7]naphthyridine-6-carbonyl)-amino]acetic acid
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| Drug Type |
Small molecular drug
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| Structure |
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Download2D MOL |
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| Formula |
C18H17N3O5
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| Canonical SMILES |
C1CC(=O)N(C2=CN=C(C(=C21)O)C(=O)NCC(=O)O)CC3=CC=CC=C3
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| InChI |
1S/C18H17N3O5/c22-14-7-6-12-13(21(14)10-11-4-2-1-3-5-11)8-19-16(17(12)25)18(26)20-9-15(23)24/h1-5,8,25H,6-7,9-10H2,(H,20,26)(H,23,24)
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| InChIKey |
RKTAODJRDMTRFE-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HIF-prolyl hydroxylase 2 (HPH-2) | Target Info | Inhibitor | [1] |
| Target's Patent Info | HIF-prolyl hydroxylase 2 (HPH-2) | Target's Patent Info | [1] | |
| KEGG Pathway | HIF-1 signaling pathway | |||
| Pathways in cancer | ||||
| Renal cell carcinoma | ||||
| Panther Pathway | Hypoxia response via HIF activation | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | |||
| References | Top | |||
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| REF 1 | Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase. US9695170. | |||
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