Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0YE4B
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| Former ID |
DNC007797
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| Drug Name |
1-phenyl-3-(2-(pyridin-4-yl)thiazol-4-yl)urea
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| Synonyms |
acyclic urea, 1; CHEMBL392228; BDBM20816
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H12N4OS
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| Canonical SMILES |
C1=CC=C(C=C1)NC(=O)NC2=CSC(=N2)C3=CC=NC=C3
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| InChI |
1S/C15H12N4OS/c20-15(17-12-4-2-1-3-5-12)19-13-10-21-14(18-13)11-6-8-16-9-7-11/h1-10H,(H2,17,19,20)
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| InChIKey |
AXDWPTZOIRLDDO-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cyclin-dependent kinase 5 (CDK5) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Axon guidance | |||
| Alzheimer's disease | ||||
| Cocaine addiction | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Panther Pathway | Axon guidance mediated by semaphorins | |||
| Pathway Interaction Database | Reelin signaling pathway | |||
| Glucocorticoid receptor regulatory network | ||||
| Lissencephaly gene (LIS1) in neuronal migration and development | ||||
| EPHA forward signaling | ||||
| Trk receptor signaling mediated by the MAPK pathway | ||||
| Reactome | DARPP-32 events | |||
| CRMPs in Sema3A signaling | ||||
| Factors involved in megakaryocyte development and platelet production | ||||
| WikiPathways | DNA Damage Response | |||
| BDNF signaling pathway | ||||
| Alzheimers Disease | ||||
| Opioid Signalling | ||||
| Semaphorin interactions | ||||
| Factors involved in megakaryocyte development and platelet production | ||||
| Nicotine Activity on Dopaminergic Neurons | ||||
| miRNA Regulation of DNA Damage Response | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors. Bioorg Med Chem. 2007 Oct 15;15(20):6574-95. | |||
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