Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Y7QY
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| Former ID |
DNC005613
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| Drug Name |
(E)-3-(4-tert-Butyl-phenyl)-N-phenyl-acrylamide
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| Synonyms |
CHEMBL426634; (2E)-3-[4-(tert-butyl)phenyl]-N-phenylprop-2-enamide; AC1NYN2M; (E)-3-(4-tert-Butyl-phenyl)-N-phenyl-acrylamide; SCHEMBL4006434; SCHEMBL4006429; MolPort-006-388-008; AVMIAJAOFXDOSN-SDNWHVSQSA-N; ZINC5903656; STK411584; BDBM50158648; AKOS003298323; 3-(4-tert-butylphenyl)-N-phenylacrylamide; ST50943451; (E)-3-(4-tert-butylphenyl)-N-phenylprop-2-enamide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H21NO
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| Canonical SMILES |
CC(C)(C)C1=CC=C(C=C1)C=CC(=O)NC2=CC=CC=C2
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| InChI |
1S/C19H21NO/c1-19(2,3)16-12-9-15(10-13-16)11-14-18(21)20-17-7-5-4-6-8-17/h4-14H,1-3H3,(H,20,21)/b14-11+
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| InChIKey |
AVMIAJAOFXDOSN-SDNWHVSQSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides. J Med Chem. 2005 Jan 13;48(1):71-90. | |||
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