Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Y5QD
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| Former ID |
DIB006280
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| Drug Name |
ENMD-1198
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| Synonyms |
EM-5171; EM-883; EM-900; Hypoxia inducible factor 1 inhibitors, EntreMed; HIF-1 inhibitors, EntreMed; HIF-1 inhibitors (cancer), EntreMed; 2-ME2 analogs (oral, cancer), EntreMed; 2-methoxyestradiol analogs (oral, cancer), EntreMed
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Company |
EntreMed
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| Structure |
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Download2D MOL |
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| Formula |
C20H25NO2
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| Canonical SMILES |
CC12CCC3C(C1CC=C2)CCC4=CC(=C(C=C34)OC)C(=O)N
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| InChI |
1S/C20H25NO2/c1-20-8-3-4-17(20)14-6-5-12-10-16(19(21)22)18(23-2)11-15(12)13(14)7-9-20/h3,8,10-11,13-14,17H,4-7,9H2,1-2H3,(H2,21,22)/t13-,14+,17-,20-/m0/s1
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| InChIKey |
YQJWOUQGXATDAE-ACNBBOPNSA-N
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| CAS Number |
CAS 864668-87-1
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ENMD-1198, a new analogue of 2-methoxyestradiol, displays both antiangiogenic and vascular-disrupting properties. Mol Cancer Ther. 2010 May;9(5):1408-18. | |||
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