Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Y5JC
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| Former ID |
DNAP001693
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| Drug Name |
Avanafil
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| Synonyms |
Stendra (TN)
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| Drug Type |
Small molecular drug
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| Indication | Erectile dysfunction [ICD-11: HA01.1; ICD-10: N48.4; ICD-9: 302.72, 607.84] | Approved | [1], [2] | |
| Company |
Vivus
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| Structure |
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Download2D MOL |
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| Formula |
C23H26ClN7O3
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| Canonical SMILES |
COC1=C(C=C(C=C1)CNC2=NC(=NC=C2C(=O)NCC3=NC=CC=N3)N4CCCC4CO)Cl
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| InChI |
1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
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| InChIKey |
WEAJZXNPAWBCOA-INIZCTEOSA-N
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| CAS Number |
CAS 330784-47-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14834924, 15132057, 17397370, 24160918, 45292193, 50284293, 57373612, 125299302, 126680642, 135264773, 136922931, 137082779, 137263447, 143177981, 160645587, 162255031, 164178031, 164194088, 164835991, 165222624, 165245576, 170502146, 174528935, 175267514, 175427065, 178104020, 185997047, 189480340, 198993783, 210275731, 210281392, 223635467, 223667975, 223700581, 223797060, 226490661, 241381281, 244115505, 249855750, 250163172, 250224291, 252066590, 252214915, 252436466
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| ChEBI ID |
CHEBI:66876
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| ADReCS Drug ID | BADD_D00192 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 5A (PDE5A) | Target Info | Modulator | [3] |
| KEGG Pathway | Purine metabolism | |||
| cGMP-PKG signaling pathway | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Reactome | cGMP effects | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7448). | |||
| REF 2 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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