Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Y2XY
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| Former ID |
DIB018467
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| Drug Name |
12R-HETE
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| Synonyms |
12r-HETE
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C20H32O3
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| Canonical SMILES |
CCCCCC=CCC(C=CC=CCC=CCCCC(=O)O)O
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| InChI |
1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+/t19-/m1/s1
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| InChIKey |
ZNHVWPKMFKADKW-ZYBDYUKJSA-N
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| CAS Number |
CAS 82337-46-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
801685, 4266114, 11038790, 14718421, 14752679, 14850506, 17395820, 26754747, 26754748, 39316570, 47217014, 48334746, 50110768, 57358869, 77183169, 92309713, 99300627, 99302145, 104046389, 113859253, 131277740, 135651371, 164757739, 179205503, 227683593, 241163503, 250132978, 252378533, 252455437, 252463821
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| ChEBI ID |
CHEBI:34144
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Leukotriene B4 receptor 2 (LTB4R2) | Target Info | Agonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Reactome | Leukotriene receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3405). | |||
| REF 2 | A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature. 1997 Jun 5;387(6633):620-4. | |||
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