Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Y0RS
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| Drug Name |
PMID25522065-Compound-20
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| Drug Type |
Small molecular drug
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| Company |
GLAXOSMITHKLINE LLC CHRISTENSEN, Siegfried, Benjamin, IV QIN, Donghui CHEN, Shenglin HUANG, Xing LI, Di LI, Fei LIN, Xiaojuan LU, Shi LV, Maoyun WU, Chengde XU, Weiliang YAN, Gang YUAN, Jianxing ZHANG, Weina ZHANG, Zhiliu
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H21ClN4O3
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| Canonical SMILES |
C1CC(N(C1)C2=NC=C(C=C2)N3C=CC(=CC3=O)OCC4=NC=C(C=C4)Cl)CO
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| InChI |
1S/C21H21ClN4O3/c22-15-3-4-16(23-11-15)14-29-19-7-9-26(21(28)10-19)17-5-6-20(24-12-17)25-8-1-2-18(25)13-27/h3-7,9-12,18,27H,1-2,8,13-14H2/t18-/m1/s1
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| InChIKey |
FLLZLALIXHIFNL-GOSISDBHSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Melanin-concentrating hormone receptor 1 (MCHR1) | Target Info | Antagonist | [1] |
| Target's Patent Info | Melanin-concentrating hormone receptor 1 (MCHR1) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. | |||
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