Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Y0ES
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| Former ID |
DNC000796
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| Drug Name |
Indirubin-3'-monoxime
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| Synonyms |
INDIRUBIN-3'-MONOXIME; indirubin-3'-oxime; 160807-49-8; indirubin-3-oxime; Indirubin-3monoxime; Indirubin-3-monoxime; 3-[3-(Hydroxyamino)-1H-indol-2-yl]indol-2-one; CHEBI:43645; Indirubin 3'-monoxime; indirubin-3'-monooxime; Indirubin-3& CHEMBL216543; CHEMBL126077; (Z)-1H,1'H-[2,3']BIINDOLYLIDENE-3,2'-DIONE-3-OXIME; UNM-0000305771; 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one; 667463-82-3; IXM; SR-01000075929; Indirubin-3; Indirubin 3-oxime; Tocris-1813; BiomolKI_000070; Indirubin-3-oxime
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H11N3O2
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| Canonical SMILES |
C1=CC=C2C(=C1)C(=C(N2)O)C3=C(C4=CC=CC=C4N3)N=O
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| InChI |
1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17-18,20H
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| InChIKey |
FQCPPVRJPILDIK-UHFFFAOYSA-N
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| CAS Number |
CAS 160807-49-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
534355, 830054, 5208370, 7888502, 10318990, 10852044, 11111310, 11114225, 11121739, 11122219, 11362862, 11365424, 11367986, 11370935, 11370936, 11373587, 11376148, 11444985, 14750770, 14775169, 17405181, 24278483, 24380763, 24716361, 26711872, 26737430, 26752251, 26752252, 26758939, 39299535, 46391346, 46392944, 46399854, 46507166, 47217061, 47589235, 47811033, 47960012, 47960013, 48110735, 48259502, 50104963, 50104964, 53777725, 53800898, 57361257, 57571268, 60791732, 75653098, 85231086
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| ChEBI ID |
CHEBI:43645
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5989). | |||
| REF 2 | An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. | |||
| REF 3 | The kinase inhibitor indirubin-3'-oxime prevents germinal vesicle breakdown and reduces parthenogenetic development of pig oocytes. Theriogenology. 2006 Mar 1;65(4):744-56. | |||
| REF 4 | Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. | |||
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