Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0XU7M
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| Former ID |
DNC006028
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| Drug Name |
NSC-663284
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| Synonyms |
NSC 663284; 383907-43-5; NSC-663284; NSC663284; CDC25 Phosphatase Inhibitor II, NSC 663284; 6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione; 6-chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione; DA3003-1; 6-Chloro-7-((2-morpholinoethyl)amino)quinoline-5,8-dione; AC1Q3HBF; AC1Q3HBE; SPS8I1; MLS006010693; SCHEMBL2556224; AC1L8E02; CTK4H9880; CHEBI:92053; DTXSID50327512; MolPort-003-983-788; HMS3268K22; BCP16027; MFCD08276924; BS0130; ZINC100002044; AKOS024456823; CS-7519; NCGC00092289-01; NCGC00092289-02
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H16ClN3O3
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| Canonical SMILES |
C1COCCN1CCNC2=C(C(=O)C3=C(C2=O)N=CC=C3)Cl
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| InChI |
1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
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| InChIKey |
BMKPVDQDJQWBPD-UHFFFAOYSA-N
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| CAS Number |
CAS 383907-43-5
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:92053
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | M-phase inducer phosphatase 3 (MPIP3) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Cell cycle | |||
| Oocyte meiosis | ||||
| Progesterone-mediated oocyte maturation | ||||
| MicroRNAs in cancer | ||||
| Panther Pathway | p53 pathway | |||
| Pathway Interaction Database | ATR signaling pathway | |||
| ATM pathway | ||||
| PLK1 signaling events | ||||
| PLK3 signaling events | ||||
| Reactome | Polo-like kinase mediated events | |||
| Cyclin B2 mediated events | ||||
| Activation of ATR in response to replication stress | ||||
| RHO GTPases activate PKNs | ||||
| Cyclin A/B1 associated events during G2/M transition | ||||
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | ||||
| WikiPathways | Monoamine Transport | |||
| DNA Damage Response | ||||
| ATM Signaling Pathway | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| Mitotic G2-G2/M phases | ||||
| Cell Cycle | ||||
| Cell Cycle Checkpoints | ||||
| miRNA Regulation of DNA Damage Response | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C. Bioorg Med Chem Lett. 2006 Jan 1;16(1):171-5. | |||
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