Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0XO2G
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| Former ID |
DIB018832
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| Drug Name |
AMG 9810
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| Synonyms |
AMG-9810; AMG9810
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C21H23NO3
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| Canonical SMILES |
CC(C)(C)C1=CC=C(C=C1)C=CC(=O)NC2=CC3=C(C=C2)OCCO3
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| InChI |
1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+
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| InChIKey |
GZTFUVZVLYUPRG-IZZDOVSWSA-N
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| CAS Number |
CAS 545395-94-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
882814, 3549920, 9283109, 16439871, 25818630, 26753279, 44865144, 49688584, 50075744, 53790930, 57408530, 76105963, 89282702, 90341516, 103464558, 108413549, 109869769, 121361842, 135332129, 135698247, 137757200, 162248063, 163565172, 164106815, 164760662, 175612731, 177748553, 178102965, 179721459, 187072159, 198981904, 202824628, 204380356, 223455460, 229139810, 229139821, 241104828, 252156440, 252366026
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| ChEBI ID |
CHEBI:92757
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Blocker (channel blocker) | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6347). | |||
| REF 2 | AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyp... J Pharmacol Exp Ther. 2005 Apr;313(1):474-84. | |||
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