Drug Information
Drug General Information | Top | |||
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Drug ID |
D0XD7V
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Drug Name |
FLX475
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Drug Type |
Small molecular drug
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199] | Phase 1/2 | [1] | |
Company |
FLX BioSouth San Francisco, CA
|
Target and Pathway | Top | |||
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Target(s) | C-C chemokine receptor type 4 (CCR4) | Target Info | Antagonist | [2] |
KEGG Pathway | Cytokine-cytokine receptor interaction | |||
Chemokine signaling pathway | ||||
Viral carcinogenesis | ||||
Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
Reactome | Chemokine receptors bind chemokines | |||
G alpha (i) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT03674567) Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination With Pembrolizumab. U.S. National Institutes of Health. | |||
REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
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