Drug Information
Drug General Information | Top | |||
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Drug ID |
D0X8XT
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Former ID |
DNCL003441
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Drug Name |
CS-0777
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Synonyms |
CS-0777; UNII-KCH74QG79A; KCH74QG79A; 827344-05-8; CS 0777; SCHEMBL1454408; CHEMBL1951587; YXEQXPNSBUIRDZ-OAQYLSRUSA-N; ZINC59872504; 1192731-63-7; 1-Butanone, 1-(5-((3R)-3-amino-4-hydroxy-3-methylbutyl)-1-methyl-1H-pyrrol-2-yl)-4-(4-methylphenyl)-
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Drug Type |
Small molecular drug
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Indication | Multiple sclerosis [ICD-11: 8A40; ICD-9: 340] | Phase 1 | [1] | |
Company |
Daiichi Sankyo
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Structure |
Download2D MOL |
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Formula |
C21H30N2O2
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Canonical SMILES |
CC1=CC=C(C=C1)CCCC(=O)C2=CC=C(N2C)CCC(C)(CO)N
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InChI |
1S/C21H30N2O2/c1-16-7-9-17(10-8-16)5-4-6-20(25)19-12-11-18(23(19)3)13-14-21(2,22)15-24/h7-12,24H,4-6,13-15,22H2,1-3H3/t21-/m1/s1
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InChIKey |
YXEQXPNSBUIRDZ-OAQYLSRUSA-N
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CAS Number |
CAS 827344-05-8
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Sphingosine-1-phosphate receptor 1 (S1PR1) | Target Info | Modulator | [2], [3] |
KEGG Pathway | FoxO signaling pathway | |||
Sphingolipid signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
NetPath Pathway | IL4 Signaling Pathway | |||
TGF_beta_Receptor Signaling Pathway | ||||
IL2 Signaling Pathway | ||||
Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | |||
S1P3 pathway | ||||
S1P1 pathway | ||||
Sphingosine 1-phosphate (S1P) pathway | ||||
PDGFR-beta signaling pathway | ||||
Reactome | G alpha (i) signalling events | |||
Lysosphingolipid and LPA receptors | ||||
WikiPathways | Signal Transduction of S1P Receptor | |||
Small Ligand GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT00616733) 12-week Safety Evaluation of Oral CS-0777 in Multiple Sclerosis Patients. U.S. National Institutes of Health. | |||
REF 2 | Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist. ACS Med Chem Lett. 2011 Mar 2;2(5):368-72. | |||
REF 3 | Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: results from a 12-week, open-label pilot study in multiple sclerosis patients. J Neuroimmunol. 2012 May 15;246(1-2):100-7. |
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