Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0X7JK
|
|||
| Former ID |
DIB019858
|
|||
| Drug Name |
TCS-359
|
|||
| Synonyms |
TCS 359
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C18H20N2O4S
|
|||
| Canonical SMILES |
COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC
|
|||
| InChI |
1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
|
|||
| InChIKey |
FSPQCTGGIANIJZ-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 301305-73-7
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
1321210, 3230603, 3354452, 4079009, 4906390, 8751927, 17000751, 24332340, 24724465, 25749477, 26758701, 40810380, 47321816, 47767674, 50112926, 51240179, 53800921, 57899417, 85787670, 87717363, 99302675, 103490072, 104069325, 104840163, 110180211, 124579771, 124659182, 134964526, 135698114, 142683481, 162023432, 162247974, 162312753, 163123665, 163688142, 164041757, 164862696, 169389923, 172820848, 178102593, 179050822, 185998766, 204372562, 208265128, 208265462, 210275001, 210280639, 223379700, 223489746, 233817153
|
|||
| ChEBI ID |
CHEBI:93427
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fms-like tyrosine kinase 3 (FLT-3) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Hematopoietic cell lineage | ||||
| Pathways in cancer | ||||
| Transcriptional misregulation in cancer | ||||
| Acute myeloid leukemia | ||||
| Central carbon metabolism in cancer | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3282-6. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.