Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0X6SJ
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| Drug Name |
Selenium compound 3
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| Synonyms |
PMID25468267-Compound-30
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| Drug Type |
Small molecular drug
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| Company |
ISIS INNOVATION LIMITED SCHOFIELD, Christopher Joseph ROSE, Nathan SEKIRNIK, Rok
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| Structure |
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Download2D MOL |
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| Formula |
C13H9NOSe
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| Canonical SMILES |
C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
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| InChI |
1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
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| InChIKey |
DYEFUKCXAQOFHX-UHFFFAOYSA-N
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| CAS Number |
CAS 60940-34-3
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:77543
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides caccae
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Ebselen (adjusted p-values: 9.96E-03). | |||
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Studied Microbe: Bacteroides fragilis enterotoxigenic
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Ebselen (adjusted p-values: 2.69E-04). | |||
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Studied Microbe: Bacteroides fragilis nontoxigenic
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis nontoxigenic was decreased by Ebselen (adjusted p-values: 4.16E-04). | |||
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Studied Microbe: Bacteroides thetaiotaomicron
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides thetaiotaomicron was decreased by Ebselen (adjusted p-values: 1.86E-03). | |||
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Studied Microbe: Bacteroides uniformis
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Ebselen (adjusted p-values: 1.80E-04). | |||
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Studied Microbe: Bacteroides vulgatus
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Ebselen (adjusted p-values: 4.28E-05). | |||
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Studied Microbe: Odoribacter splanchnicus
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Ebselen (adjusted p-values: 2.40E-03). | |||
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Studied Microbe: Parabacteroides distasonis
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Ebselen (adjusted p-values: 2.00E-04). | |||
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Studied Microbe: Parabacteroides merdae
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Ebselen (adjusted p-values: 5.61E-06). | |||
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Studied Microbe: Prevotella copri
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Ebselen (adjusted p-values: 4.14E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium adolescentis was decreased by Ebselen (adjusted p-values: 1.68E-05). | |||
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Studied Microbe: Bifidobacterium longum
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium longum was decreased by Ebselen (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Ebselen (adjusted p-values: 2.74E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eggerthella lenta was decreased by Ebselen (adjusted p-values: 1.67E-04). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Erysipelatoclostridium ramosum
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Erysipelatoclostridium ramosum was decreased by Ebselen (adjusted p-values: 4.83E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Ebselen (adjusted p-values: 7.48E-07). | |||
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Studied Microbe: Clostridium perfringens
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Ebselen (adjusted p-values: 6.32E-06). | |||
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Studied Microbe: Coprococcus comes
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Ebselen (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Dorea formicigenerans
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Ebselen (adjusted p-values: 5.61E-06). | |||
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Studied Microbe: Enterocloster bolteae
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Enterocloster bolteae was decreased by Ebselen (adjusted p-values: 4.72E-03). | |||
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Studied Microbe: Eubacterium eligens
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium eligens was decreased by Ebselen (adjusted p-values: 7.37E-06). | |||
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Studied Microbe: Eubacterium rectale
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Ebselen (adjusted p-values: 1.65E-04). | |||
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Studied Microbe: Lacrimispora saccharolytica
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lacrimispora saccharolytica was decreased by Ebselen (adjusted p-values: 1.37E-04). | |||
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Studied Microbe: Roseburia hominis
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Ebselen (adjusted p-values: 2.30E-03). | |||
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Studied Microbe: Roseburia intestinalis
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Ebselen (adjusted p-values: 1.66E-04). | |||
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Studied Microbe: Ruminococcus bromii
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Ebselen (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Ruminococcus gnavus
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Ebselen (adjusted p-values: 6.73E-06). | |||
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Studied Microbe: Ruminococcus torques
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Ebselen (adjusted p-values: 2.87E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Lactobacillus paracasei
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|
[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lactobacillus paracasei was decreased by Ebselen (adjusted p-values: 6.45E-05). | |||
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Studied Microbe: Streptococcus parasanguinis
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus parasanguinis was decreased by Ebselen (adjusted p-values: 1.75E-06). | |||
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Studied Microbe: Streptococcus salivarius
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[1] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus salivarius was decreased by Ebselen (adjusted p-values: 6.24E-04). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Lysine-specific demethylase 4A (KDM4A) | Target Info | Inhibitor | [2] |
| Target's Patent Info | Lysine-specific demethylase 4A (KDM4A) | Target's Patent Info | [2] | |
| References | Top | |||
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| REF 1 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 2 | KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. | |||
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