Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0X4IA
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| Former ID |
DPR000045
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| Drug Name |
FK778
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| Synonyms |
Manitimus; FK 778; HMR 1715; MNA 715; Malononitrilamide 715; X 920715; FK-778; HMR-1715; MNA-715; MNA-X 920715; Malononitrilamide-715; X-920715; (2Z)-2-[hydroxy-[4-(trifluoromethyl)anilino]methylidene]-3-oxohept-6-ynenitrile; 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide; 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynoic acid
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| Drug Type |
Small molecular drug
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| Indication | Kidney/heart transplant rejection [ICD-11: NE84; ICD-10: T86; ICD-9: 996] | Discontinued in Phase 2 | [1] | |
| Company |
Astellas
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| Structure |
 |
Download2D MOL |
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| Formula |
C14H10F3N3O2
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| Canonical SMILES |
C1=CC(=CC=C1C(F)(F)F)NC(=O)C(=C(CCC#N)O)C#N
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| InChI |
1S/C14H10F3N3O2/c15-14(16,17)9-3-5-10(6-4-9)20-13(22)11(8-19)12(21)2-1-7-18/h3-6,21H,1-2H2,(H,20,22)/b12-11-
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| InChIKey |
OQUXVPJVBSENGK-QXMHVHEDSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dihydroorotate dehydrogenase (DHODH) | Target Info | Modulator | [2] |
| KEGG Pathway | Pyrimidine metabolism | |||
| Metabolic pathways | ||||
| Panther Pathway | De novo pyrimidine ribonucleotides biosythesis | |||
| Pathwhiz Pathway | Pyrimidine Metabolism | |||
| Reactome | Pyrimidine biosynthesis | |||
| WikiPathways | Metabolism of nucleotides | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21. | |||
| REF 2 | Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model. Transplantation. 2003 Dec 15;76(11):1627-9. | |||
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