Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0X1VJ
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| Former ID |
DIB007519
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| Drug Name |
AGI-1067
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| Synonyms |
AGZ-1067; Succinic acid 2,6-di-tert-butyl-4-[1-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-1-methylethylsulfanyl]phenyl monoester
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| Drug Type |
Small molecular drug
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| Indication | Artery stenosis [ICD-11: BD52; ICD-10: I51.89] | Phase 3 | [1] | |
| Company |
AtheroGenics
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| Structure |
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Download2D MOL |
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| Formula |
C35H52O5S2
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| Canonical SMILES |
CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(C(=C2)C(C)(C)C)OC(=O)CCC(=O)O)C(C)(C)C
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| InChI |
1S/C35H52O5S2/c1-31(2,3)23-17-21(18-24(29(23)39)32(4,5)6)41-35(13,14)42-22-19-25(33(7,8)9)30(26(20-22)34(10,11)12)40-28(38)16-15-27(36)37/h17-20,39H,15-16H2,1-14H3,(H,36,37)
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| InChIKey |
RKSMVPNZHBRNNS-UHFFFAOYSA-N
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| CAS Number |
CAS 216167-82-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Second phase insulin secretion (SPI secr) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00066898) ARISE Aggressive Reduction of Inflammation Stops Events. U.S. National Institutes of Health. | |||
| REF 2 | AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets. Mol Cell Endocrinol. 2010 Jul 29;323(2):246-55. | |||
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