Drug Information
Drug General Information | Top | |||
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Drug ID |
D0X0AM
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Former ID |
DIB021260
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Drug Name |
ZK159222
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Synonyms |
C410228; ZK 159222
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C32H48O5
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Canonical SMILES |
CCCCOC(=O)C1(CC1)C(C=CC(C)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C)O
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InChI |
1S/C32H48O5/c1-5-6-18-37-30(36)32(16-17-32)29(35)14-9-21(2)26-12-13-27-23(8-7-15-31(26,27)4)10-11-24-19-25(33)20-28(34)22(24)3/h9-11,14,21,25-29,33-35H,3,5-8,12-13,15-20H2,1-2,4H3/b14-9+,23-10+,24-11-/t21-,25-,26-,27+,28+,29-,31-/m1/s1
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InChIKey |
SPARTCPUGRJFRS-PBDCIXLPSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Vitamin D3 receptor (VDR) | Target Info | Antagonist | [2] |
KEGG Pathway | Endocrine and other factor-regulated calcium reabsorption | |||
Mineral absorption | ||||
Tuberculosis | ||||
NetPath Pathway | IL4 Signaling Pathway | |||
Panther Pathway | Vitamin D metabolism and pathway | |||
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
Direct p53 effectors | ||||
RXR and RAR heterodimerization with other nuclear receptor | ||||
Retinoic acid receptors-mediated signaling | ||||
Validated transcriptional targets of deltaNp63 isoforms | ||||
Validated transcriptional targets of TAp63 isoforms | ||||
Reactome | Nuclear Receptor transcription pathway | |||
WikiPathways | Ovarian Infertility Genes | |||
Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
Nuclear Receptors Meta-Pathway | ||||
Vitamin D Receptor Pathway | ||||
Drug Induction of Bile Acid Pathway | ||||
Nuclear Receptors | ||||
Vitamin D Metabolism |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2789). | |||
REF 2 | Carboxylic ester antagonists of 1alpha,25-dihydroxyvitamin D(3) show cell-specific actions. Chem Biol. 2000 Nov;7(11):885-94. |
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