Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0WE3O
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| Former ID |
DAP000071
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| Drug Name |
Morphine
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| Synonyms |
Avinza; Kadian; Morphine Sulfate; Depodur; Astramorph Pf; Duramorph Pf; Infumorph; Ms Contin; Oramorph Sr
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| Drug Type |
Small molecular drug
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| Indication | Chronic pain [ICD-11: MG30; ICD-10: R52.1, R52.2; ICD-9: 338.2, 780] | Approved | [1] | |
| Therapeutic Class |
Analgesics
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| Company |
Eurohealth International Sarl
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| Structure |
 |
Download2D MOL |
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| Formula |
C17H19NO3
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| Canonical SMILES |
CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
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| InChI |
1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
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| InChIKey |
BQJCRHHNABKAKU-KBQPJGBKSA-N
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| CAS Number |
CAS 57-27-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4681, 597738, 841232, 7888991, 7980017, 8017560, 8144201, 11041479, 14775492, 14897787, 39321145, 46394454, 46505161, 48416295, 49992759, 53788344, 56312319, 56312595, 56313877, 57359248, 79236356, 87544101, 93166305, 96024921, 103169185, 103914789, 126677732, 127553079, 127829358, 134337399, 134970862, 135650624, 137003124, 137178956, 139157571, 152105973, 160963643, 175268905, 175442171, 179150686, 223674390, 223677431, 223738295, 226395290, 241102130
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| ChEBI ID |
CHEBI:17303
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| ADReCS Drug ID | BADD_D01498 ; BADD_D01499 ; BADD_D01500 ; BADD_D01619 | |||
| SuperDrug ATC ID |
N02AA01
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| SuperDrug CAS ID |
cas=000057272
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [2], [3] | |||
| Metabolic Reaction | Deglucuronidation and hydrolysis | |||
| Metabolic Effect | Increase activity; Increase toxicity | |||
| Description | Morphine can be metabolized by gut microbiota through deglucuronidation and hydrolysis, which results in the increase of drug's activity and toxicity. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Opioid receptor mu (MOP) | Target Info | Modulator | [4] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Estrogen signaling pathway | ||||
| Morphine addiction | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Enkephalin release | ||||
| Pathway Interaction Database | IL4-mediated signaling events | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | TCR Signaling Pathway | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | ||||
| Opioid Signalling | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Gut microbiota modulates drug pharmacokinetics. Drug Metab Rev. 2018 Aug;50(3):357-368. | |||
| REF 3 | Predicting and Understanding the Human Microbiome's Impact on Pharmacology. Trends Pharmacol Sci. 2019 Jul;40(7):495-505. | |||
| REF 4 | Antianalgesia: stereoselective action of dextro-morphine over levo-morphine on glia in the mouse spinal cord.J Pharmacol Exp Ther.2005 Sep;314(3):1101-8. | |||
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