Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0WA3E
|
|||
| Former ID |
DIB020067
|
|||
| Drug Name |
IOX2
|
|||
| Synonyms |
compound 6
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C19H16N2O5
|
|||
| Canonical SMILES |
C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O
|
|||
| InChI |
1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)
|
|||
| InChIKey |
CAOSCCRYLYQBES-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 931398-72-0
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
24778472, 40663068, 162009848, 162011982, 163620906, 163686227, 164045273, 164194039, 172821464, 174006887, 174531553, 184817439, 189614653, 223377760, 223404287, 223705116, 233771982, 241376998, 242060113, 242589787, 247732403, 249565909, 252158071, 252160572, 252215599, 252449236, 252450617, 252553668
|
|||
| ChEBI ID |
CHEBI:95087
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HIF-prolyl hydroxylase 2 (HPH-2) | Target Info | Inhibitor | [1] |
| Lysine-specific demethylase 2A (KDM2A) | Target Info | Inhibitor | [1] | |
| Lysine-specific demethylase 5C (KDM5C) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | HIF-1 signaling pathway | |||
| Pathways in cancer | ||||
| Renal cell carcinoma | ||||
| Panther Pathway | Hypoxia response via HIF activation | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol. 2013 Jul 19;8(7):1488-96. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.