Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0W9SL
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| Former ID |
DNCL003811
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| Drug Name |
LY2523355
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| Synonyms |
Litronesib
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| Drug Type |
Small molecular drug
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| Indication | Acute myeloid leukaemia [ICD-11: 2A60] | Phase 2 | [1] | |
| Company |
Lilly
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H37N5O4S2
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| Canonical SMILES |
CCNCCS(=O)(=O)NCC1(N(N=C(S1)NC(=O)C(C)(C)C)C(=O)C(C)(C)C)C2=CC=CC=C2
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| InChI |
1S/C23H37N5O4S2/c1-8-24-14-15-34(31,32)25-16-23(17-12-10-9-11-13-17)28(19(30)22(5,6)7)27-20(33-23)26-18(29)21(2,3)4/h9-13,24-25H,8,14-16H2,1-7H3,(H,26,27,29)/t23-/m0/s1
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| InChIKey |
YVAFBXLHPINSIK-QHCPKHFHSA-N
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| CAS Number |
CAS 910634-41-2
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Kinesin-like protein KIF11 (KIF11) | Target Info | Modulator | [2] |
| Reactome | MHC class II antigen presentation | |||
| Kinesins | ||||
| WikiPathways | MHC class II antigen presentation | |||
| Kinesins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01416389) A Study of LY2523355 in Patients With Breast Cancer. U.S. National Institutes of Health. | |||
| REF 2 | Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39. | |||
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