Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0W8UW
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| Former ID |
DNC013314
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| Drug Name |
AMG-628
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| Synonyms |
AMG-628; UNII-G8JW58493W; G8JW58493W; N-{4-[(6-{4-[(1R)-1-(4-fluorophenyl)ethyl]piperazin-1-yl}pyrimidin-4-yl)oxy]-1,3-benzothiazol-2-yl}acetamide; 862269-93-0; AMG 628; AMG628; AMG-628, (R)-; SCHEMBL3841997; GTPL4130; CHEMBL226574; BDBM20581; QUHZTEMPQQZPNB-MRXNPFEDSA-N; MolPort-029-996-161; KS-00003MQ7; Piperazinylpyrimidine analogue, 16p; ZINC14974185; AKOS022193590; MB-0047; Acetamide, N-(4-((6-(4-((1R)-1-(4-fluorophenyl)ethyl)-1-piperazinyl)-4-pyrimidinyl)oxy)-2-benzothiazolyl)-; UNII-28J966TN3X component QUHZTEMPQQZPNB-M
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD-11: MG30-MG3Z] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C25H25FN6O2S
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| Canonical SMILES |
CC(C1=CC=C(C=C1)F)N2CCN(CC2)C3=CC(=NC=N3)OC4=C5C(=CC=C4)SC(=N5)NC(=O)C
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| InChI |
1S/C25H25FN6O2S/c1-16(18-6-8-19(26)9-7-18)31-10-12-32(13-11-31)22-14-23(28-15-27-22)34-20-4-3-5-21-24(20)30-25(35-21)29-17(2)33/h3-9,14-16H,10-13H2,1-2H3,(H,29,30,33)/t16-/m1/s1
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| InChIKey |
QUHZTEMPQQZPNB-MRXNPFEDSA-N
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| CAS Number |
CAS 862269-93-0
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| PubChem Compound ID | ||||
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4130). | |||
| REF 2 | Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacok... J Med Chem. 2007 Jul 26;50(15):3528-39. | |||
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